An essential diagnostic technique for identifying antibodies to the syphilis-causing bacteria Treponema pallidum is the TPHA (Treponema Pallidum Hemagglutination) test. Because of its high specificity, this test is usually used to confirm a syphilis diagnosis when results from another test, like the VDRL or RPR, point to a potential infection. The primary goal of TPHA is to detect and validate syphilis infections; however, because late-stage syphilis can lead to cardiovascular problems, TPHA has important implications for health heart diagnostics (HHD).

Untreated syphilis can develop to harm various organ systems, including the cardiovascular system. It is a multi-stage illness. Syphilitic aortitis, or inflammation of the aorta, is one of the most serious consequences of late-stage syphilis. This may result in